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SIGA starts phase 1 study of SIGA-246 for smallpox
By Lisa Kerner
Erie, Pa., Mary 2 - SIGA Technologies, Inc.'s lead drug candidate for smallpox, SIGA-246, has begun phase 1 human clinical trials examining the drug's safety and pharmacokinetics. The company expects to collect all data from the study next month.
The double-blind, randomized, placebo-controlled, ascending single-dose phase 1 clinical trial is being performed on healthy volunteers.
SIGA-246 has demonstrated significant antiviral activity in various animal models of poxvirus disease, including the complete protection of golden ground squirrels from lethal doses of monkeypox virus, according to a company news release.
New York City-based SIGA develops novel products for the prevention and treatment of serious infectious diseases, with an emphasis on products for biological warfare defense.
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