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ProMetic says study shows reduction in blood-borne brain disease using PRDT technology
By Lisa Kerner
Erie, Pa., Feb. 16 - Pathogen Removal and Diagnostic Technologies Inc. (PRDT) said its endogenous (blood-borne) infectivity study is complete and that data shows the removal of blood-borne transmissible spongiform encephalopathy (TSE) infectivity from whole blood below the limit of detection of the bioassay.
TSEs are fatal brain diseases that include Bovine Spongiform Encephalopathy or "mad cow disease" in cattle and Creutzfeldt-Jakob Disease (vCJD) in humans, according to a company news release.
A study update will be presented at the Cambridge Healthtech Institute's 10th International Conference TSE meeting on March 8, with results to be published later this year.
The study was co-sponsored by PRDT and its manufacturing and commercial partner, MacoPharma, a European provider of blood collection systems and transfusion solutions.
PRDT's resin, incorporated into the MacoPharma prion filter, P-CAPT, is the first to demonstrate reduction of TSE prions from whole blood, the company said.
According to the study results, none of the 100 laboratory animals inoculated with infected whole blood, which had been filtered through devices containing the PRDT resin, developed disease after 540 days incubation, compared to 14 of the 99 inoculated with unfiltered whole blood.
"This study has very positive implications in the fight against vCJD, the fatal human form of mad cow disease, which is perhaps the greatest emerging threat to the blood supply," ProMetic president and chief executive officer Pierre Laurin said in the release.
Montreal-based PRDT is a joint-venture company formed by The American National Red Cross, ProMetic Life Sciences Inc., ProMetic BioSciences Ltd, Dr. Robert G. Rohwer and Dr Ruben G. Carbonell. PRDT's goal is to develop products and devices to remove and detect different pathogens from biological sources.
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