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Published on 5/31/2006 in the Prospect News Biotech Daily and Prospect News PIPE Daily.

New Issue: Isis Pharmaceuticals releases terms of $75 million equity line

By Sheri Kasprzak

New York, May 31 - Isis Pharmaceuticals, Inc. revealed the details on its previously announced $75 million equity line with Azimuth Opportunity Ltd.

Azimuth has agreed to buy shares of Isis at discounts ranging from 3.8% to 5.3%, depending upon the company's stock price, over 18 months.

The line may only be drawn from 16 times.

The proceeds will be used to develop the company's ISIS 113715 to treat type 2 diabetes. The rest will be used for preclinical trials of ISIS 369645 to treat asthma and for ISIS 353512 to treat cardiovascular disease and inflammation.

Isis, based in Carlsbad, Calif., is a pharmaceutical company focused on treatments for cardiovascular, metabolic and inflammatory disorders.

Issuer:Isis Pharmaceuticals, Inc.
Issue:Equity line
Amount:$75 million
Tenor:18 months
Price:At discounts ranging from 3.8% to 5.3%, depending upon stock price
Warrants:No
Investor:Azimuth Opportunity Ltd.
Settlement date:May 30
Stock symbol:Nasdaq: ISIS
Stock price:$7.46 at close May 30

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