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Evolutec study to compare rEV131 and prednisolone in treatment of post-operative eye inflammation
By Lisa Kerner
Charlotte, N.C., June 20 - Evolutec Group plc said it began a 150-patient, double-blind, proof-of-concept phase 2 trial with its lead compound, rEV131, in the treatment of inflammation following cataract surgery.
The trial will compare twice-daily dosing of rEV131 to prednisolone, dosed four times a day, and a placebo over a two-week period.
The primary endpoints of the trial are flare and cell counts. Results are expected by the end of the year.
Taking place at 10 ophthalmic surgical centers in the United States, this trial follows a successful preclinical study showing rEV131 to be as effective as prednisolone 1.0%.
Evolutec believes the value of the post-cataract surgery inflammation market to be about $500 million.
Based in Reading, U.K., Evolutec is a clinical-stage biopharmaceutical company specializing in allergy, inflammation and autoimmune diseases.
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