Roche, Entelos to collaborate in metabolic disease research

By E. Janene Geiss

Philadelphia, May 24 - Roche and Entelos, Inc. announced Wednesday a two-year collaboration in metabolic disease research.

Under the agreement, Roche will provide research and development funding and milestone payments and Entelos will conduct biosimulation research using its Metabolism PhysioLab platform, which uses a "virtual patient" approach to predict the effects of a drug on metabolic pathways and/or biomarkers, according to a company news release.

Roche said this approach will be useful in analyzing existing preclinical and clinical data to optimize future clinical trials.

Financial terms were not disclosed.

Entelos said its technology will be applied across several research programs and is expected to contribute information along the discovery and development path from compound optimization through to clinical trial design.

The Metabolism PhysioLab platform is a large-scale mathematical model of human physiology that supports research in the areas of obesity and type 2 diabetes.

The platform includes the physiology and pathophysiology of metabolic disease, as well as the underlying cellular mechanisms. Processes that the model can simulate include the digestion, absorption, storage, mobilization and oxidation of carbohydrate, fat and protein, as well as the hormonal regulation of these processes.

Hoffmann-La Roche Inc., based in Nutley, N.J., is the U.S. pharmaceuticals headquarters of the Roche Group, a Basel, Switzerland, health care group with core businesses in pharmaceuticals and diagnostics.

Entelos is a Foster City, Calif., life sciences company that applies engineering principles and mathematical modeling approaches to simulate human biology.

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